While the CJC-1295 peptide falls under the category of a hormone just like testosterone, it’s a bit different:
It’s a peptide hormone, not a steroid hormone.
However, it’s what is known as a Growth Hormone Releasing Hormone (GHRH), and is commonly used for boosting performance in the gym.
There are many names for this particular substance, and therefore confusion abounds.
Understanding what these names mean and how they came into being before going into detail about this is the first step.
When looking for this compound, you’ll notice there is CJC-1295 mixed with a Drug Affinity Complex (DAC).
You’ll also notice CJC-1295 without DAC, which is also known as Mod GRF 1-29.
What is the difference? How are these substances different from human growth hormone (HGH)? What are the benefits and risks of using them?
Knowing the answers to these questions is essential if you’re looking into CJC-1295 for performance enhancement, especially when purchasing online. Buy HGH-X2 online here.
Table of Contents
The CJC-1295 peptide is a synthetic compound that was created for the purpose of increasing protein synthesis and muscle tissue growth.
It is also held to improve recovery times, help cut body fat, and bolster the immune system.
But what is CJC-1295 DAC? At it’s most basic definition, it is a derivative of GHRH.
This quick breakdown will help clear up some confusion.
This might be complicated, but it’s an important fact to note:
CJC-1295 without DAC is still commonly referred to as CJC-1295, but it isn’t—it’s actually Mod GRF, an injectable peptide that works in the same way as GHRHs.
CJC-1295 is synonymous with CJC-1295 with DAC, and Mod GRF 1-29 is synonymous with CJC-1295 without DAC.
The community of performance enhancing drug users and researchers interested in this area can also become baffled by these terms as researchers use different names.
Some vendors name their products by all these names for easier identification, but many use one name or the other, adding to the jumble.
The original name is thought to be tetra substituted GRF (1-29). The second iteration of this compound was a modification on the first, so Modified GRF 1-29 was coined.
A researcher named DatBtrue first used the word Mod GRF 1-29, shortening it more. This name’s ease of use caused many to adopt it, and it became widely popular.
CJC-1295 without DAC is the most commonly used name today. The readers have to be knowledgeable that this is the same product as Mod GRF 1-29 even though it is described in different terms.
So what is this GRF?
Actually, GRF denotes growth hormone releasing factor. We all know growth hormone (HGH) is the hormone important for the growth and development of our body. This is a derivative which increases the release of this HGH or human growth hormone which is a peptide hormone.
Usually, in the human body, the growth hormone is released due to stimulation by growth hormone releasing hormone (GHRH), which is also a peptide hormone secreted by the hypothalamus in the brain.
When GHRH is modified to be given exogenously or from the outside of the body, it is known as Growth hormone Releasing Factor or GRF 1-29.
Ready for more names?
This will help clear up the CJC-1295 vs. Sermorelin question.
Basically, referring to the breakdown at the beginning of this section, Sermorelin is first generation GHRH derivative and CJC-1295 is third generation GHRH derivative.
GRF 1-29 is also known as Sermorelin, which is a trade name for this product. Mod GRF 1-29 (CJC-1295 without DAC) is derived from Sermorelin/GRF 1-29.
CJC-1295 with DAC is derived from Mod GRF 1-29/CJC-1295 without DAC.
Sermorelin or GRF 1-29 can be considered a first generation derivative of GHRH.
When this product is further modified, we get Mod GRF 1-29. Therefore, this compound, also referred to as CJC-1295 without DAC, can be considered a second generation derivative of GHRH.
There is a third generation derivative as well. It is called CJC-1295 with DAC, standing for Drug Affinity Complex. This DAC is actually a modification to the peptide chain so that the affinity and half life of the drug are increased.
As it is a commonly known derivative. In case it is still not clear, it bears repeating: many people name the second generation drug CJC-1295 without DAC. This name is the one commonly being used today.
With a basic idea about what these names mean, let us take a look at the constitution and mechanisms of these products.
As mentioned earlier, the GHRH and its derivatives are peptide hormones. Peptides are actually protein based hormones.
All these derivatives have a similar, more enhanced action of the GHRH produced endogenously or by the body.
Mod GRF 1-29 was first discovered in Canada and mentioned in the medical literature in 2005.
The protein or the peptide chain of this hormone has 29 amino acids. It is important to know the structure of this substance to fully understand how it functions in stimulating the receptors in the anterior pituitary gland to release growth hormone.
The neuro endocrine system employs short polymers of amino acids called peptides as hormones, hormone-releasing factors, neuro-modulators, and neurotransmitters.
By placing the amino acids in a precise location in a three dimensional structure, proteins can perform complex catalytic and physical tasks.
In order to do so, the polypeptide chains are arranged in a strong and efficient chemical formation.
There are four orders of protein structure.
In peptide hormones, the placement of amino acids and peptide chains is important because when binding to receptors, tiny modifications in the structure can lead to a difference in function.
When slightly modified, the same hormone can have either greater affinity or weaker affinity depending on the protein shape or the structure.
The Growth Hormone Releasing Hormone (GHRH) is naturally secreted by the arcuate nucleus in the hypothalamus of the brain.
It has 44 amino acids. However, researchers have discovered that only the first 29 amino acids are important in executing the function of GHRH as equally effectively as the 44 amino acid structure.
The scientists then formulated GRF 1-29 which contains only these 29 amino acids.
However, many studies have discovered that this derivative lasts for only a short time with a half life of about 5 minutes.
Usually, the pituitary receptors need more prolonged stimulation for it to release an adequate amount of growth hormone for peak function. It was reported that at least 30 minutes was required for the full release of the human growth hormone.
This required a more potent derivative which is resistant to breakdown by enzymes. It led to the discovery of Mod GRF 1-29 which was developed alongside many other derivatives and had the most promising results.
The modification included replacement of amino acids at 2, 8, 15 and 27 sites. This resulted in a prolonged half life of minimum 30 minutes. Just to reiterate for clarity, Mod GRF 1-29 is what is referred to when people use the term CJC-1295 without DAC.
So that clarified the differences between HGH, GRF 1-29, and CJC-1295 without DAC.
So what’s the difference between CJC-1295 without DAC (Mod GRF 1-29) and CJC-1295 in terms of their function?
The biggest is injection frequency.
While CJC-1295 creates a series of small Growth Hormone pulses from the pituitary gland, Mod GRF creates larger pulses.
This means CJC-1295 requires less injections to see results, while Mod GRF requires more frequent injections.
It also means that CJC-1295 with DAC has a longer half-life and its concentrations in the blood remains more steady.
Modified GRF 1-29 is very different to anabolic steroids.
As explained above, CJC-1295 without DAC stimulates the pituitary gland to release human growth hormone. This growth hormone is synthesized naturally from the body and not administered exogenously. It is released in a pulsatile manner and not continuously.
As the end product which causes the effects is human growth hormone, CJC-1295 without DAC can be considered a human growth hormone product.
Bodybuilders often regard the Mod GRF 1-29 cycles the same way they regard exogenous human growth hormone cycles. As mentioned, these type of cycles are very much different from the anabolic steroid cycles, and they need specialized care.
In anabolic steroid cycles, we encounter terms such as “beginner cycles” or “advanced cycles”. However, there are no such cycles in Mod GRF 1-29 cycles because it is a natural hormone already in the body.
There are so many uses to CJC-1295 without DAC with guides for scheduling and dosing frequency according to each specific need. There are mainly three applications that many people use Mod GRF 1-29 cycles for.
CJC-1295 without DAC is a new drug on the market. Therefore, not many legal restrictions are applied to it as of yet.
If you’re looking to buy CJC-1295, you won’t have much trouble.
As a research chemical that is not regulated by the U.S. Food and Drug Administration, it can be purchased without a prescription.
Since this peptide is easy to manufacture, it can be found in the open market with no legal problems in most countries.
However, it is sold as a substance to be used for research purposes. Therefore, users will only find it in research grade vials an in the form of freeze dried powder.
The product will need to be reconstituted using sterile water.
CJC-1295 without DAC is available as a research product in countries like the UK, Canada, and United States.
As this is a product still under research, there are no medically sanctioned optimal doses, pharmacodynamics, and pharmacokinetics of the drug.
Although there are no legal restrictions, this drug has not yet been legally cleared for human use.
Peptide Sciences is a common site for such compounds that lie within the fuzzy area of unregulated substances.
Here’s the thing though:
While companies selling research chemicals are generally more reliable than those selling illegal anabolics (since they don’t have as much reason to counterfeit), you still never know what you’re getting.
In addition, these products are sold for research use only, which means using them for bodybuilding is illegal in many jurisdictions.
While purchasing them is not illegal if you claim to be using them for research purposes, this can be hard to prove.
When purchased from Peptide Sciences, CJC-1295 costs $52.50 for 5 mg.
The products can vary according to the chemical companies, and usually Mod GRF 1-29 cost is around $22 – $45 for a 2 mg vial.
This price will range depending on where you purchase from—Transformix Peptides sells 2 mg for around the same price.
In general, expect to pay at least $50 for this product.
The CJC-1295 with DAC dosage recommendation is around 2 mg twice a week, along with a daily Growth Hormone Releasing Peptide (GHRP).
What about Mod GRF (CJC-1295 without DAC)?
This compound is held to require injections of around 100 mcg to 200 mcg one to three times per day.
This CJC-1295 without DAC and much other growth hormone releasing peptide products are still under research and quite new to the market.
Since there are ongoing clinical trials and not enough time for their completion, currently there is no clinical data regarding dosing and schedules accurately. Although there are common protocols regarding dosing schedules online, these have not been validated by proper clinical trials and solid evidence.
Many growth hormones releasing peptides are still under research, but this has not prevented the performance enhancing community from taking these drugs.
Bodybuilders, athletes, and interested users take these drugs to improve their performance even though robust data is lacking.
Given their overlapping effects on the body (in regards to the release of Human Growth Hormone), combining GHRHs like CJC-1295 with GHRPs, such as Ipamorelin, is commonplace.
GHRPs are often referred to as Ghrelin mimetics, based on the “hunger hormone” Ghrelin which is also a peptide involved in signal transmission.
The main function of Mod GRF 1-29 is to act on the receptors of the anterior pituitary gland and signal the increased release of human growth hormone and its production.
Usually, growth hormone is released in a pulsatile manner. These derivatives can cause massive pulses. The effects will be similar to what is seen by administering growth hormone over the long term.
However, there is one drawback.
The amount of time this endogenous growth hormone stays in the circulation is relatively less than synthetic growth hormone. Therefore, in order to maintain peak blood levels, several administrations of Mod GRF 1-29 are needed throughout the day.
When CJC-1295 without DAC/Mod GRF 1-29 is combined with a Ghrelin mimetic, which is also called GHRP or Growth Hormone Releasing Hexapeptide, the human growth hormone pulses from the anterior pituitary will be much higher and sustained than using Mod GRF 1-29 alone.
Some of these Ghrelin mimetics include Hexarelin, Ipamorelin, GHRP-2, and GHRP-6. Therefore, GHRH derivatives and GHRP are often combined to allow a synergistic effect, amplifying the release of growth hormone from the anterior pituitary.
One of the most common combinations is CJC-1295 + Ipamorelin.
By combining these compounds, you’re creating a very anabolic internal environment that is held to pave the way for increased muscle development.
Combining Mod GRF 1-29 with a ghrelin derivative will result in improved function of Mod GRF 1-29.
The derivatives such as GHRP-6 or Ipamorelin have many mechanisms of actions to carry out this function. They can directly stimulate the pituitary gland and aid in releasing human growth hormone along with CJC-1295 without DAC or Mod GRF 1-29.
They can also inhibit the somatostatin hormone which is an obstacle to the release of growth hormone from the pituitary gland. Therefore GHRP or Ghrelin mimetics can potentiate the pulsatile release of human growth hormone by its synergistic action.
According to a 1994 study, if 100 mcg of growth hormone releasing hormone products are taken, there will be a release of 25 ng /ml of human growth hormone.
However, if this was combined with GHRP or Ghrelin mimetics, the pulse of human growth hormone could be as much as 130 ng /ml.
Although not common, you also need to consider CJC-1295 DAC side effects.
Like anabolic steroids, performance enhancement comes at a price.
Some of these adverse effects are:
These might not seem as extreme as steroids, but they can still be unpleasant.
In addition, one of the biggest dangers of ordering online is not knowing exactly how pure your product is, so you really never know how your body is going to react.
No matter what CJC-1295 with DAC reviews might say, or what its benefits are for performance enhancement, there’s always a natural solution.
In this case, we’re going to look at HGH-X2—a supplement that acts naturally on your pituitary gland to release HGH into your bloodstream.
With a boost in this anabolic hormone, you’ll see plenty of great results.
What kind of results?
Well, pretty much the same as those obtained from CJC-1295:
Increased muscle growth, protein production, and body fat use.
The main takeaway is this: you don’t need synthetic products to excel in the gym.
In combination with willpower, a proper diet, and reliable supplements, you can get amazing results.
And this isn’t all talk:
You’re guaranteed to see results within 30 days, and that’s not just a fable.
“My weight was 97 kg,” said one customer. “I used HGH-X2 for 45 days with a good food program and now I am 90 kg with pure muscle.”
But don’t take it from us: check out the other feedback of this great product.
The CJC-1295 peptide brings results, but great results can also be obtained from natural products.
We all want fast results in the gym.
Unfortunately, this desire sometimes clouds the importance of their quality.
Using HGH-X2 and similar products, you can get quality gains that last using completely natural ingredients.CJC-1295 BenefitsCJC-1295 DacCJC-1295 DosageCJC-1295 PeptideCJC-1295 ResultsCJC-1295 ReviewsCJC-1295 Side EffectsCJC-1295 Without DacGhrhGHRP-6 PeptideGrowth Hormone Releasing HexapeptideGrowth Hormone Releasing HormoneHGH PeptidesPeg mgf PeptideSermorelin Ghrp2