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Growth hormone releasing hexapeptide is a hormone.
Users know it interchangeably as either a protein or a peptide hormone although it belongs to a family of human growth hormone secretagogues.
It’s a mouthful, but a secretagogue is a substance that encourages or triggers release of something, in this case, growth hormone.
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Table of Contents
Before digging deeper into how growth hormone releasing hexapeptide works, it’s important to understand at least the basics about growth hormone.
Growth hormone manufactured in the body is called somatotropin.
Human growth hormone is manufactured in the pituitary gland, which is located in the brain.
The pituitary gland is known as the master gland of the body.
This is because it is responsible for the maintenance and secretions of other hormones including testosterone (manufactured in the male testes and its small amounts by women’s ovaries) as well as insulin-like growth factor (manufactured in the liver).
Working together, human growth hormone (HGH), testosterone, and insulin-like growth factor are beneficial in the growth and development of numerous tissues in the body, most notably muscle – at least as far as bodybuilders are concerned.
Synthetic or laboratory manufactured growth hormone (HGH) is called somatropin.
Synthetic growth hormone is often used in medical treatments for those diagnosed with childhood or adult-onset of growth hormone deficiencies.
Growth hormone plays a role in more than just muscle development. It contributes to and is involved in:
The main responsibility of body-produced growth hormone-releasing hormone (GHRH) is to stimulate the secretion of growth hormone.
What’s the difference between growth hormone-releasing hormone and a growth hormone releasing peptide?
Growth hormone releasing hexapeptide is one of many secretagogues that stimulate the pituitary gland to release growth hormone.
The “hexapeptide” defines a specific growth hormone releasing peptide more commonly known as GHRP-6 (a six-sided peptide). In medical terms, it’s known as His-Dtrp-Ala-Trp-Dphe-Lys-NH2. 
What exactly does it do? It stimulates not only endogenous (body-produced) growth hormone secretions, but can increase levels of insulin-like growth factor-1 (IGF-1 manufactured in the liver).
In medical scenarios, GHRP-6 is commonly used to treat a number of growth hormone deficiencies, but it’s also effective in the treatment of some eating disorders, and muscle wasting scenarios (cachexia).
How does it work? Growth hormone releasing peptides not only increase secretions of growth hormone, but secretions of Ghrelin, known as the “hunger hormone” to increase appetite – which bodybuilders or athletes should be aware of before using.
Before use of GHRP-6, bodybuilders and athletes should also be aware that putting a hormone or a compound into the body that can interfere with, disrupt, or otherwise influence normal hormone production and secretions does risk the potential for unexpected side effects.
Dosage recommendations vary depending on how it’s used and what the athlete or bodybuilder expects from it.Check out the best growth hormone stacks with HGH pills here.
Before purchasing from any manufacturer, be aware that they’re not generally readily available for sale from reputable pharmaceutical or chemical research companies.
This is without prior authorization for purchase from a medical institution or professional.
You may find warnings that state “this product is intended as a research chemical only”.
A number of faux pharmaceutical and peptide research companies to do sell a variety of peptide products to bodybuilders and athletes. One popular manufacturer sells 10 mg GHRP-6 for approximately $30 per vial.
Bodybuilders should also be aware of faulty and misleading labeling practices. Purchasing a vial that claims 99% purity from an underground lab doesn’t necessarily prove true in every case.
Dosage recommendations for growth hormone and secretagogues varies widely depending on users.
Generally, dosage for use of growth hormone releasing hexapeptide averages 1 mcg per kilogram of body weight, although some bodybuilders start with 100 mcg per dose regardless of weight.
Increasing dosage of this type of hormone peptide will actually decrease its efficacy because the ghrelin receptors (which is what GHRP-6 targets) are already fully saturated at the 100 mcg level.
At any dosage, watch for side effects. Diet is important in regard to efficacy.
It is recommended that dosage follow at least a two hour wait following consumption of a meal or no sooner than approximately 30 minutes before eating a meal that contains fats are carbohydrates, which are perceived to reduce the secretion of human growth hormone.
Note – Human growth hormone is released by the pituitary gland through impulses throughout the day, most effectively at night during sleep.
In order to maintain a somewhat steady release of HGH while using growth hormone releasing hexapeptide, experienced users recommend dosages averaging three hours apart or:
Some bodybuilders inject twice-daily while others inject more frequently. Growth hormone releasing hexapeptide results are not immediate and can take several weeks for observable changes to be noticed.
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