Growth hormone releasing hexapeptide is a hormone.
Users know it interchangeably as either a protein hormone or a peptide hormone.
It can also be labeled a Growth Hormone Releasing Peptide (GHRP), which is why it is also called GRHP-6.
GHRP-6 is a peptide or protein hormone that is made up of a 6 amino acids polypeptide chain.
The chain also contains unnatural D-amino acids synthetically created explicitly for the release of HGH from the pituitary gland, qualifying GHRP-6 as a proper HGH secretagogue.
It’s a mouthful, but a secretagogue is a substance that encourages or triggers release of something, in this case, growth hormone. Buy HGH-X2 online here.
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Before digging deeper into how growth hormone releasing hexapeptide works, it’s important to understand at least the basics about growth hormone.
Growth hormone manufactured in the body is called somatotropin.
Human growth hormone is manufactured in the pituitary gland, which is located in the brain.
The pituitary gland is known as the master gland of the body.
This is because it is responsible for the maintenance and secretions of other hormones including testosterone (manufactured in the male testes and its small amounts by women’s ovaries) as well as insulin-like growth factor (manufactured in the liver).
Below are some summarized points about this GHRP.
Working together, human growth hormone (HGH), testosterone, and insulin-like growth factor are beneficial in the growth and development of numerous tissues in the body, most notably muscle – at least as far as bodybuilders are concerned.
Synthetic or laboratory manufactured growth hormone (HGH) is called somatropin.
Synthetic growth hormone is often used in medical treatments for those diagnosed with childhood or adult-onset of growth hormone deficiencies.
Growth hormone plays a role in more than just muscle development. It contributes to and is involved in:
The main responsibility of body-produced growth hormone-releasing hormone (GHRH) is to stimulate the secretion of growth hormone.
What’s the difference between growth hormone-releasing hormone and a growth hormone releasing peptide?
Growth hormone releasing hexapeptide is one of many secretagogues that stimulate the pituitary gland to release growth hormone.
The “hexapeptide” defines a specific growth hormone releasing peptide more commonly known as GHRP-6 (a six-sided peptide). In medical terms, it’s known as His-Dtrp-Ala-Trp-Dphe-Lys-NH2. 
What exactly does it do? It stimulates not only endogenous (body-produced) growth hormone secretions, but can increase levels of insulin-like growth factor-1 (IGF-1 manufactured in the liver).
In medical scenarios, GHRP-6 is commonly used to treat a number of growth hormone deficiencies, but it’s also effective in the treatment of some eating disorders, and muscle wasting scenarios (cachexia).
How does it work?
Growth hormone releasing peptides not only increase secretions of growth hormone, but secretions of Ghrelin, known as the “hunger hormone” to increase appetite – which bodybuilders or athletes should be aware of before using.
Not to be confused with GHRH, GHRPs like Growth Hormone Releasing Hexapeptide interact with the hypothalamus’ and pituitary gland’s receptors that are different from those that GHRH interacts with.
The HGH secretagogue receptor, now commonly referred to as the Gherkin receptor, is stimulated by GHRP-6. GHRP-6 does not stimulate the GHRH receptor—that’s the job of Growth Hormone Releasing Hormones like CJC-1295 without DAC.
GHRP-6 stimulates an HGH pulsatile release from the pituitary gland. This is usually the strongest within the first 20-30 minutes and normally lasts for several hours.
The half-life of GHRP-6 ranges between 15 minutes and 60 minutes.
Due to the ability of GHRP to stimulate the release of HGH from the pituitary gland, the effects from GHRP-6 can be the same as the effects of synthetic HGH administered for a longer time.
But with GHRP-6, the time that the HGH remains in the bloodstream is less than the time that synthetic HGH will remain circulated.
The amount of HGH in the bloodstream is maintained for a few hours, but the most significant HGH blood plasma levels are achieved within the first 30 minutes of administering GHRP-6.
This is the reason why physique builder recommend administering GHRP at multiple times during the day to maintain steady and high HGH levels.
The HGH effects from the utilization of GHRP-6 can include increased muscle mass, reduced body fat, increased stamina, improved sleep quality, increased rate of healing, increased strength and increased health and general well-being.
Before use of GHRP-6, bodybuilders and athletes should also be aware that putting a hormone or a compound into the body that can interfere with, disrupt, or otherwise influence normal hormone production and secretions does risk the potential for unexpected side effects.
Dosage recommendations vary depending on how it’s used and what the athlete or bodybuilder expects from it.
Most of the side effects are related to HGH, since ramping up endogenous production of this hormone if the main effect of GHRP-6.
HGH side effects can include headaches, hypoglycemia, carpal tunnel syndrome, and flu-like nausea.
GHRP-6 has been linked with a host of side effects unique to GHRP-6 itself.
This is in addition to the possible side effects which are as a result of the elevation in HGH. Some of these side effects consist of the following:
Enhanced Prolactin section is also included as a side effect of GHRP-6. This can lead to lactating nipples.
This is not a common occurrence, but it can occur in individuals who are sensitive. GHRP-6 shows the capacity to cause secretion of Prolactin and Cortisol, but other studies have indicated that the increase of Cortisol and Prolactin in a majority of the test subjects did not show any changes at 100mcg GHRP-6 doses or lower.
Doses higher than 100mcg are said to elevate the secretion of prolactin, if only slightly. At these minimal levels, there is less possibility of lactation occurring.
Nonetheless, there have been reports of lactation from some users which can either be the result of too many elevated doses of GHRP-6 or of a pre-existing sensitivity.
Bodybuilders address the issue of excess prolactin through a prolactin adversary like Bromocriptine, Cabergoline, Vitamin B6 or Pramipexole.
Dizziness & Light-headedness:
GHRP-6 have been reported to lead to “head rushes” followed by a sharp pain which can feel like needles and pins.
Physique builders who have experienced this adverse reaction report that the pain can be quite severe. This effect may also come as a spell of light-headedness or dizziness.
This effect is broadly understood to be a signal that the pituitary gland is being stimulated by the peptide, and it is a side effect associated with most HGH secretagogues.
Chronic stimulation of hunger:
Generally speaking, GHRPs will cause hunger because they mirror the actions of the body’s hormone Ghrelin. This side effect has been proven both clinically and anecdotally to be the most pronounced with GHRP-6 when compared to all other GHRPs.
GHRP-6 has the tendency to generate an intensity of appetite that is frequently described as “painful hunger,” and this effect is commonly confused as an episode of hypoglycemia.
The hunger resulting from the use of GHRP-6 is basically the peptide reacting to the receptors of Ghrelin which communicate hunger to different areas of the brain.
There is no anecdotal evidence or study which shows the readouts if hypoglycemic blood glucose following the administration if GHRP-6.
The hunger is widely known to subside after a meal. There have also been reports from various users that the hunger intensity vanished many weeks into the cycles of GHRP, without vanishing totally.
Before purchasing from any manufacturer, be aware that they’re not generally readily available for sale from reputable pharmaceutical or chemical research companies.
This is without prior authorization for purchase from a medical institution or professional.
You may find warnings that state “this product is intended as a research chemical only”.
A number of faux pharmaceutical and peptide research companies to do sell a variety of peptide products to bodybuilders and athletes. One popular manufacturer sells 10 mg GHRP-6 for approximately $30 per vial.
Bodybuilders should also be aware of faulty and misleading labeling practices. Purchasing a vial that claims 99% purity from an underground lab doesn’t necessarily prove true in every case.
Dosage recommendations for growth hormone and secretagogues varies widely depending on users.
Generally, dosage for use of growth hormone releasing hexapeptide averages 1 mcg per kilogram of body weight, although some bodybuilders start with 100 mcg per dose regardless of weight.
Increasing dosage of this type of hormone peptide will actually decrease its efficacy because the ghrelin receptors (which is what GHRP-6 targets) are already fully saturated at the 100 mcg level.
At any dosage, watch for side effects. Diet is important in regard to efficacy.
It is recommended that dosage follow at least a two hour wait following consumption of a meal or no sooner than approximately 30 minutes before eating a meal that contains fats are carbohydrates, which are perceived to reduce the secretion of human growth hormone.
Note – Human growth hormone is released by the pituitary gland through impulses throughout the day, most effectively at night during sleep.
In order to maintain a somewhat steady release of HGH while using growth hormone releasing hexapeptide, experienced users recommend dosages averaging three hours apart or:
Some bodybuilders inject twice-daily while others inject more frequently. Growth hormone releasing hexapeptide results are not immediate and can take several weeks for observable changes to be noticed.Does Sermorelin Work ReviewsGhrhGhrp 6 PeptideGrowth Hormone Releasing HexapeptideGrowth Hormone Releasing HormoneHGH PeptidesHuman Growth FactorIncrelexMecaserminMod Grf 1 29Peg mgf DosagePeg mgf PeptidePeg mgf ResultsPegylated Mechano Growth FactorSermorelin Ghrp2