You thought hormones were released when the body needs them, but did you know that one master gland called the pituitary gland is responsible for releasing them by numerous hormone secreting glands in the body?
The same goes for growth hormone-releasing hormone, known as GHRH.
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GH is a protein that is made up of approximately 190 amino acids.
These acids are produced or synthesized and then secreted by cells that are called somatotrophs, from inside the anterior or frontal lobe of the pituitary gland.
What’s the big deal about GH, also known as somatotropin? Somatropin has a number of direct and indirect physiological effects on the body.
One of the indirect effects of Somatropin is modulated for the most part by insulin-like growth factor, known as IGF-1, which causes the long ends of bones to grow.
This has an effect on the length of bone growth in growing children and adolescents.
Another effect of GH is known as a direct effect, defining its capabilities to bind to target cell receptors. For example, fat cells (known as adipocytes) have growth hormone receptors.
GH can stimulate these receptors to break down triglycerides as well as their capabilities of inhibiting the accumulation of lipids or fats that circulate in the bloodstream. There are also GH inhibiting hormones.
Growth hormone-releasing hormone or GHRH, is defined as a peptide created in the hypothalamus gland. For this reason GHRH is defined as the hypothalamic neurohormone. The hypothalamus gland sits just above the pituitary gland in the brain.
GHRH stimulates the production and secretion of GH from the pituitary gland.
While the pituitary gland is considered the master gland of the body because it has control over so many other hormone glands, it should be noted that it takes its directions from and is subordinate to the hypothalamus.
The hypothalamus is mainly responsible for carbohydrate metabolism, fat metabolism, body temperature, and believe it or not, emotions that can affect your appetite, your blood pressure, heart beat, and even sexual reflexes.
The function of GHRH has more to do with simple growth and development however.
It is also believed to protect the body against bacterial toxins.
The US National Library of Medicine and the National Institutes of Health have conducted studies on this topic (“Protective effect of GHRH agonist and bacterial toxin- induced pulmonary barrier dysfunction.”).
GHRH has also been linked to aid in wound healing. As mentioned, the basic function of GHRH is to stimulate the production and release of GH in the pituitary gland.
This growth is not only limited to bone growth, but to the growth, rejuvenation, and recovery of cellular tissues in the body.
In fact, GHRH has been linked to cardiac repair following a myocardial infarction (heart attack).
One article, published in Communicative and Integrative Biology (“GHRH and wound healing“) provides a fascinating look into the potential of the hormone in regulating a number of pathological as well as physiological processes throughout the body.
A number of synthetic growth hormone-releasing hormones have been under development, one of which is Tesamorelin, resulting from development of HGH releasing factor analogues which don’t cause as many side effects as other forms of GH therapy including recombinant HGH therapy (often prescribed for GH deficiency disorders).
However, it should be noted that the long-term safety and efficacy of such drugs in the treatment of AIDS and HIV related complications has been studied in clinical trials not exceeding 52 weeks, and that the effects of the treatment cannot last “beyond the duration of treatment.”
(“Long-term safety and effects of tests a moral and, a GH releasing factor analogues, and HIV patients with abdominal fat accumulation.”)
Individuals diagnosed with GH deficiencies or dysfunction of the pituitary or hypothalamus gland may benefit from a number of treatments and therapies to regulate optimal endocrine system function.
A number of natural, safe, and legal dietary supplements found on the marketplace today are well suited to encourage the pituitary gland to increase secretions.
If you or someone you know has been diagnosed with such a deficiency, take the time to learn more about the endocrine system and its hormones and how they affect your psychological as well as physiological health and wellness.
Further study and research into the GHRH and its capabilities to provide beneficial and therapeutic treatments for a number of medical issues and health complications continues to be studied.
GH and growth hormone-releasing hormone functions are fascinating studies in the intricacies of the workings of the human form. Understanding these functions, at least it basic levels, can promote health and wellness on a personal level. Gonadotropin is another type.Growth Hormone Before and AfterGrowth Hormone BodybuildingGrowth Hormone CycleGrowth Hormone DeficiencyGrowth Hormone EffectsGrowth Hormone for SaleGrowth Hormone FunctionGrowth Hormone InjectionsGrowth Hormone PillsGrowth Hormone Releasing HexapeptideGrowth Hormone Releasing HormoneGrowth Hormone SecretagogueGrowth Hormone Side EffectsGrowth Hormone SteroidGrowth Hormone SupplementsGrowth Hormone TabletsGrowth Hormone TherapyGrowth Hormone Treatment