Human growth hormone, otherwise known as HGH, is a hormone in the body that regulates growth and development.
Synthetic forms are often given to older adults in a form of growth hormone therapy to help rebuild muscle mass.
It can also reduce fat tissue that is common in aging processes.
Known in generic terms as somatropin, it is available in roughly 24 brand-name drugs.
Prescription-only somatropin injections are relatively common among older adults, but there are safer, more natural ways to increase levels of HGH through the use of dietary supplements.
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Growth hormones like HGH are produced and secreted by the pituitary gland, located in the brain.
Like other hormones, HGH is responsible for the regulation of vital organ activities and is very important in health and wellness as we age.
It was given the name “human growth hormone” because it was noted to produce its greatest amount of secretions during the adolescent years.
While HGH does help to regulate growth, the hormone is responsible for more than how tall you grow. In fact, HGH is perceived as one of the most complex hormones in the human body.
Commonly known as somatic troponin, a peptide hormone that encourages cellular proliferation or reproduction, has the potential to regenerate cells in the human body.
Those interested in maintaining useful figure, stamina, endurance, and of course, muscle growth and maintenance of those muscles often turn to prescription strength HGH.
But it should be noted early on that no drug, not even synthetically created growth hormone, should ever be considered a miracle drug, or a “fountain of youth” component to health and wellness.
It is true that endogenous HGH as produced by the pituitary gland accelerates growth in children.
In adults, it also aids in regulating a person’s body composition are ratio of muscle to fat, height, and muscular development, but also bone growth, levels of body fluids required for numerous functions and activities in the body, as well as metabolism of fats and sugars.
Its impact on vital organ health and wellness continues under study.
Laboratory created (synthetic) HGH was developed in the mid-19 80s. It was then approved by the Food and Drug Administration for very specific clinical uses for children as well as adults.
Children benefited from HGH injections in the treatment of idiopathic (unknown) short stature or insufficient growth that was caused by medical issues including but not limited to:
Any use of human growth hormone for other than medical reasons or treatments is considered misuse and abuse of the drug.
It’s no secret that bodybuilders and athletes often take drugs like HGH to promote and accelerate benefits and results when it comes to increased muscle mass, strength, performance, and endurance, but risks associated with such use should not be ignored.
Endogenous or body produced human growth hormone is known as somatotropin, and is manufactured in the anterior portion of the pituitary gland.
The hormone is then released into the bloodstream. The release of growth hormone from the pituitary gland is not a continuous process, but rather secreted in pulses of sorts every few hours.
The release of the growth hormone from the pituitary gland is controlled by yet another hormone known as growth hormone releasing hormone, which is manufactured and secreted by the hypothalamus gland.
Hormones work in conjunction with one another. Endogenous HGH levels can increase not only through exercise, but due to stress, and low levels of glucose (blood sugar). Most growth hormone is manufactured during sleep.
One of the most natural ways to trigger an increase of growth hormone in deficient adults is to assess their sleep habits and patterns and encourage more sleep time.
The hypothalamus, which behaves much like a thermometer in the body, can also tell if levels of HGH are too high.
In such a case, it releases another hormone known as somatostatin that tells the pituitary gland to stop producing and secreting HGH until the levels are once again balanced.
The mechanism of action of growth hormone is directly impacted by the function of growth hormone receptors.
Any activity or function and body is directly related to certain abilities of cells to find or target other cells known as receptors.
This can be explained more simply as an object being directed to a specific locations such as an airplane to a terminal gate, a ship into a specific docking slip, or sliding around peg into a round hole and not a square one.
In the most simple human growth hormone definition, hormone receptors trigger event cascades which contribute to what are called as a second messengers which then initiate molecular interactions that can in any way alter the physiological environment of a cell.
This process is known as signal transduction. The secretion of the hormone that sends these instructions are known as the first messengers, and the masses jurors that initiate molecular activities or interactions are known as the second messengers.
Growth hormone is an example of a hormone that triggers a second messenger known as protein kinase activity.
This activity can stimulate metabolism to the binding of growth hormone to its preset peers (growth hormone receptors) other molecular interactions are involved in this process and involve signaling pathways, signal transduction, and a variety of enzymatic activities.
The end result is alterations or changes in metabolism and growth.
Of course, the entire process and cascade of events from the manufacturer synthesis of growth hormone in the pituitary gland and how it triggers and influences other hormones and metabolic functions in the body is quite complex.
But when used within medical scenarios, HGH can certainly provide a number of benefits to overall health and wellness.
According The Mayo Clinic, adults who have been diagnosed with growth hormone deficiencies can benefit from synthetic injections to facilitate:
When it comes to oxidation, think about rust can do to metal in a car. That’s what oxidation can do to cells, tissues, and organs in the body.
While HGH achieves its highest levels of secretions during our teenage years, after that it can decline by approximately 14% every decade.
For this reason, medical researchers have long been interested in delving deeper into the connection between declining levels of HGH and aging processes.
Human growth hormone therapy was developed, using synthetic products given in injections to (and sometimes even reverse) a number of age-related mental as well as physical decline scenarios.
It’s also been used in the treatment of some additional disorders that are not age-related.
In most cases, individuals diagnosed with a deficiency that does not involve natural decline through aging are effectively treated with synthetic growth hormones; most commonly children going through the adolescent stages of development.
Human growth hormone replacement therapy, through supplements and prescription-only injections, have been studied for years. Scientific literature reports have noted a number of benefits that include but are not limited to:
Some studies have determined that HGH is also a very effective therapy for individuals diagnosed with AIDS and helps to reverse wasting syndrome that involves muscle loss (cachexia) and severe weight declines, as well as boosting immune system function.
Dosage recommendations for HGH depend on the age of the individual being treated and the medical condition being treated. HGH/somatropin has a variety of dosage recommendations for adults being treated for:
Dosage recommendations may also be altered depending on overall health and wellness.
For example, adjustments to dosage must be made in cases where an individual is undergoing dialysis, has been diagnosed with any metabolic or liver dysfunction, kidney dysfunction, and so forth.
In most cases, adult doses of HGH are recommended in weight-based or non-weight-based situations.
For example, weight-based dosages may start out at 0.004 mg per kilogram subcutaneously on a daily basis, or 0.04 mg per kilogram weekly, divided into even dosages, with no more than 0.016 mg per kilogram daily or 0.08 mg per kilogram weekly.
Non-weight-based dosage recommendation averages 0.2 mg subcutaneously daily, (with a range of 0.15 mg to 0.3 mg daily).
Bodybuilders and athletes often inject higher than recommended doses of anabolic steroids, growth hormone, and growth factors into their body to accelerate results and benefits.
Such is common when bodybuilders devise combinations of HGH into a “cocktail” with other drugs, both prescription and over-the-counter.
Administration of drugs is also defined in milligram equivalencies to international units (IU).
For example, medical usage for somatropin and intramuscular or subcutaneous administration averages 1 IU to 3 IU daily for an average adult male (weight ranges will factor into such dosage recommendations.
The sample given is for an average-weight adult male). Growth hormone bodybuilding users often take as much as 6 IU a day, which equates to 2 mg per day.
You can see the difference.
Such high doses can increase the risk of potential and relatively common side effects that include water retention, hypoglycemia, uncomfortable sensations on the skin (often likened to a pins and needles effect), and of course, the risk for organ damage and accelerating growth of pre-existing yet undiagnosed cancers.
After all, growth hormone makes things grow – including cancers.
Studies have shown that indeed, human growth therapy benefits are real and effective, but it’s not available to everyone. Not only are legal injections of HGH only available through prescription, but they are expensive.
Some therapies, depending on situation, can cost $20,000 a year or more, depending on which HGH therapy clinic you go to!
Before deciding on human growth hormone to enhance exercise or to help slow down aging processes and damage caused by decline in growth hormone levels, it’s important to research scientific studies to determine the efficacy of numerous options, including dietary supplements.
An article published by the Harvard Medical School addresses many of the pros and cons associated with therapies (prescription and supplement).
It recommends that, like with any supplement designed to enhance health and wellness or weight loss, should always be carefully supervised and combined with a healthy lifestyle including diet and exercise.
As with anything, a number of considerations and recommendations for taking a supplements should be noted. Children should not be given HGH before consulting with a pediatrician.
In many cases, HGH supplements can stimulate the body to synthesize more than needed, leading to adverse effects.
The side effects associated with somatropin are not to be ignored. While some are simply mild and annoying, others can be much more serious. A few of the most common include:
More serious side effects associated with HGH/somatropin injections include:
Before taking HGH/somatropin, be aware of potential country indications. Drug manufacturers list minor, moderate, and major drug interactions of somatropin.
Any potential users of HGH injections for non-medical use should always consider that putting any drug into the body when it is not needed can contribute to a number of adverse and unexpected results.
One of the most “feared” by bodybuilders is the development of acromegaly. Bodybuilders often believe that if used carefully, side effects and adverse reactions will not occur. However, this is not always true.
Acromegaly is a side effect of high levels of growth hormone in the body and can occur when the pituitary gland, with no other influences, produces high amounts of growth hormone, which are often caused by benign tumors on the pituitary gland itself.
When injected by bodybuilders, the risks of overgrowth are present as well.
In some cases, acromegaly does respond well to medical treatment, including discontinuation of human growth hormone injections. In some cases, surgery may be required to deal with the overgrowth of connective tissues in the face, the hands, or the feet.
In some cases, not even surgery can repair damage done to bone tissues. Such surgical procedures are not only expensive, but don’t always produce expected results or restore an individual to be pre-acromegaly state.
Long-term studies regarding side effects or adverse reactions have not yet been completely studied, but it is recommended that an individual on HGH therapy or taking supplements avoid sweet foods, as blood sugar levels can be negatively affected.
If you’re interested in HGH supplements to help or reverse damage caused by normal aging processes, talk to your doctor about benefits and drawbacks. Be informed.
Human growth hormone can benefit some, but may not be recommended in certain circumstances.
Before looking into HGH injections for sale and injecting them into the body that can wreak havoc with hormone and metabolic functions in the body, consider natural alternatives.
They may take a little longer to become effective, but they’re a lot safer and legal to use.
Even if some forms of human growth hormone for sale are available over the counter in your country and is considered legal, check with the World Anti-Doping Agency before use to ensure that the ingredients or components of any drug, natural, herbal, or prescription strength in nature, are not banned prior to competitions or sporting events.