Sermorelin acetate is classified as a type of growth hormone.
Actually, it’s an analog manufactured in the laboratory to mimic the effects of body-produced growth hormone-releasing hormone – GHRH.
What does it do? How does it work in the body, and is it safe to use by bodybuilders?
An analog simply defines the similarity of one thing to another.
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Here’s how it works:
The pituitary gland is known as the master gland of the body because it is responsible for the manufacture and secretion of hormones from numerous hormone glands in the body.
It receives its instructions to either manufacture or inhibit release of specific hormones by the hypothalamus. Both glands are located in the brain.
The hypothalamus is responsible for numerous functions, one of which is to maintain balance of fluids in the body.
Think of the hypothalamus as the body’s thermostat, constantly making minor adjustments for optimal organ health and function.
The pituitary gland manufactures growth hormone known as somatotropin or HGH/GH, in addition to its responsibility of monitoring other hormone secretions.
When the hypothalamus senses that levels of growth hormone in the body are not adequate, it sends a message or signal to the pituitary gland in the form of a neurohormone (hypothalamic neurohormone).
That hormone is growth hormone-releasing hormone or GHRH, that stimulates secretion of growth hormone from the pituitary.
Sermorelin acetate is simply a “substitute” for this endogenous neurohormone that has been created in a laboratory, commonly indicated in individuals with some type of growth hormone or growth factor deficiency.
Sermorelin, known in research environments as GRF 1-29, was developed back in the 1970s and most commonly used in combination with testosterone replacement therapy.
It’s also been used in some antiaging therapies as well as treatment for adult-onset growth hormone deficiencies.
Technically, it is defined as a secretagogue, or a trigger for the stimulation and secretion of growth hormone in the pituitary gland.
In a laboratory environment, synthetic Sermorelin acetate has been modified to contain a fraction of the amino acid sequence that endogenous or body-produced human growth hormone manufacturers (29 as compared to 191).
That sequence contains portions of human growth hormone-releasing hormone.
In the body, growth hormone-releasing hormone like Sermorelin acetate has an affinity for binding to specific cellular receptors involved in the production of energy.
More specifically, the component can activate cyclic adenosine monophosphate (cAMP) pathways as well as the phospholipase C pathway.
Phospholipase C is a type of “backup” or secondary messenger system involved in communication between cells in the body.
Growth hormone contains amino acids.
Amino acids are essential in the formation of protein. Protein is essential for cellular growth, including that of muscle.
For this reason, bodybuilders often turn to growth hormone drugs, secretagogues, and growth factors to help achieve their bodybuilding goals.
Sermorelin can cost anywhere from $200 to $500 per month, which is a much lower price than HGH therapy.
Sermorelin acetate is used in medical scenarios to treat some pituitary gland deficiencies that have an impact on growth and development.
Bodybuilders take advantage of the Sermorelin acetate benefits because of its activities – not only as a growth hormone, but due to its anabolic or tissue-building potential.
Growth hormone also has an influence on cellular longevity and can reduce catabolic effects on muscle cells and fibers.
How is it used? In medical scenarios, Sermorelin acetate is recommended only in the treatment of children diagnosed with growth hormone deficiencies. It is not intended nor recommended for use in someone whose hormone levels are balanced.
Introducing an excess of one hormone over another in the body can result in imbalances, dysfunction, and unexpected side effects.
Can HGH help you lose weight? Some studies have indicated that it can help with cutting fat. HGH Fragment 176-191 is designed more specifically for weight loss.
Dosage recommendations by bodybuilders are inconsistent, depending where you find them.
Looking at medical references, dosage (for children) started at approximately 0.03 mg per kilogram of body weight daily.
Bodybuilders often inject (subcutaneously) anywhere from 0.2 mg to 0.5 mg daily.
This equates to 200 mcg to 500 mcg on a daily basis. While medical scenarios indicate the drug was to be given at bedtime, bodybuilders will often divide the daily dose into a morning and evening routine.
As mentioned, hormone balances in the body are carefully maintained by the hypothalamus.
Higher levels of one hormone such as testosterone, growth hormone, or insulin-like growth factor-1 can trigger a number of issues not only with their singular and specific hormonal function, but in the functions of other hormones that work together to produce certain activities.
Is Sermorelin FDA approved? Yes.
Before making a Sermorelin acetate purchase or resorting to the use of other synthetic growth hormones and secretagogues like Hexarelin, understand how they work in the body.
Know what they are medically used for, as well as the risks of injecting such drugs into a body with normal hormone production and balances.Does Sermorelin Work ReviewsGhrhGHRP-2 Benefits Side EffectsGHRP-2 Dosage CycleGHRP-2 GHRP-6 IpamorelinGHRP-2 Peptide ResultsGHRP-2 ReviewsGHRP-6 PeptideGrowth Hormone Releasing HexapeptideGrowth Hormone Releasing HormoneHGH PeptidesPeg mgf PeptideSermorelin AcetateSermorelin Dosage for BodybuildingSermorelin GHRP2