Testosterone base generally defines the foundation or base of synthetic testosterone.
In the laboratory, synthetic testosterone is often modified by the inclusion of an ester.
Labs can create numerous variations of testosterone this way.
Esters attached to a base drug – in this case a testosterone base – can have an influence on absorption rate, such as slowing it down.
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It’s fast-acting and very powerful.
Bodybuilders often take this exogenous form of testosterone pre-workout for an extra boost of strength and energy.
On bodybuilding forums you can find numerous Testosterone base recipes for painless Testosterone Suspension injections, but be very careful with what you put into your body.
Side effects can be very severe.
Esters are generally defined as the result of chemical reactions of a type of alcohol and a carboxylic acid; a chemical compound that is attached to testosterone base (or numerous other basic hormones or drugs) to enhance its solubility.
This is especially true in the case of oil-based testosterone vs water based, which slows down the release rate of the testosterone as it’s injected into the body.
Numerous esters are often attached to testosterone depending on brand and manufacturer. The most common include:
As noted, each has a slightly different molecular structure, although all do contain carbon, hydrogen, and oxygen.
Each ester attached to a testosterone base has slightly different effects in regard to its absorption rate as well as half-life.
Due to the nature of un-esterified testosterone base (testosterone suspension), its use in full-length anabolic steroid cycles is not common.
Most times, it is used as a pre-event and pre-workout boost, a supplementary compound to an anabolic cycle, or an injectable kickstarting compound.
The Testosterone Suspension (no ester) half-life is less than 24 hours.
Because of its very short window of release, Testosterone Suspension requires daily injections to maintain peak levels in the bloodstream.
This is felt to be much less convenient when compared to esterified forms of Testosterone, which may only require a shot once or twice a week.
Some people prefer to run full-length testosterone suspension cycles because it is widely regarded as the most potent injectable testosterone on the market.
One of the benefits often attributed to test base cycles is that they can be cut short when compared to several other types of anabolic cycles.
It is thought that the user can still accomplish great gains without engaging in an 8-12 week cycle.
This is possible because of the fast acting and powerful nature of testosterone suspension.
Because it is un-esterified, it has a markedly short window of release compared with Testosterone Cypionate, Testosterone Enathate, and other esterified forms of testosterone.
It also contains more of the hormone per 100 mls of the injected drug because the weight of an ester doesn’t need to be factored out.
These are the key reasons why users run full testosterone suspension cycles despite the inconvenient nature of testosterone suspension, which often involves frequent and painful injections over a short period.
The cycle length of a typical testosterone base cycle is around 4-6 weeks, a length that is nearly half of several other anabolic cycles’ lengths.
It takes most other anabolic steroids 4-6 weeks just to start working actively at highest blood plasma levels in the human body.
But for testosterone suspension, mass and strength gains can be visibly noticed well before 4 weeks time.
Users report achieving all the gains they wanted within 4-6 week. Though users can engage in testosterone suspension cycles for a much longer time, only a few users run the cycles longer owing to the frequent, painful injections.
By the time the testosterone suspension cycle is completed after the fourth week, most users are already satisfied with the gains and results. The tradeoff is frequent, irritating injections.
Most of the time, testosterone base is normally used as a supplementary compound to an anabolic cycle that includes other anabolic steroids as the base steroidal compounds.
In this case, only small doses of testosterone suspension are used, and this provides less aromatization of the compound to estrogen.
It is also used in addition to other non-aromatizable anabolic steroids at higher doses.
Testosterone suspension-based cycles are considered to be reserved for the brave and daring because of the frequency of injections.
Physique builders will normally advise against this, and suggest a cycle based on an esterified variant of testosterone instead.
While these cycles will take longer to complete, they save the performance user from the possibility of running out of injection sites because of the pain of injecting everyday.
Dosages of testosterone base with varying esters will depend on the ester.
We have a lot of information on this site about the common dosage schedules for different ester variants of testosterone.
In this section, we will focus on common dosages for Testosterone Base without esters, also known as Testosterone Suspension.
An average when it comes to testosterone replacement therapy dosage can range anywhere from 50 mg to 300 mg, with the middle ground found between 200 mg to 250 mg every two weeks.
Dosage recommendations will be determined on an individualized basis.
Bodybuilders using any ester-modified testosterone base should first look to the medical recommendations in regard to dosage for that ester.
However, most bodybuilders are only interested in the efficacy and speed at which with results can be obtained.
For this reason, bodybuilders often inject higher than recommended levels of testosterone into the body with varying results in regard to benefits and potential drawbacks.
A 4 week performance cycle dosage of Testosterone Base might look like this.
This is a sample of a beginner testosterone suspension cycle. For this cycle, testosterone suspension is the only compound that is used.
Even advanced steroid users will engage in testosterone-only cycles (albeit, perhaps not a testosterone suspension-only cycles) because it is very powerful for strength and muscle mass on its own.
Testosterone base is known to act quickly in the body, which requires daily injections but also takes far less time before results start becoming visible.
In starter testosterone cycles like this, users report gaining as high as 20-30lbs of bulk in only 4 weeks.
This kind of result might take testosterone enanthate cycle 12-14 weeks to achieve.
Testosterone suspension might appeal to people who want to run shorter cycles that gives them the freedom to quickly start and end the cycle.
Because testosterone suspension acts quickly and is fairly aromatizable, the 20-30lbs of bulk cannot be 100% pure lean mass.
Most times, the gained mass is not top quality, and there is a lot of water weight and bloating owing to the build-up of estrogen from aromatization.
To avoid these negative side effects, users will regularly cycle an aromatase inhibitor.
Side effects of a testosterone base with or without an ester attached can also be influenced for the better or worse with the combination of other forms of testosterone depending on their milligram strength and potency.
Bodybuilders and athletes also often take drugs that minimize the potential side effects of aromatization or conversion of testosterone and estrogen in the male body.
Men do produce small amounts of estrogen to counterbalance increasing levels of testosterone.
The higher the levels of testosterone in the male body, the higher the levels of estrogen. It’s this activity that contributes to undesired side effects such as:
Body-produced testosterone is known as endogenous; one of the many hormones produced by the human body.
It’s a primary male hormone manufactured mainly in the testicles, although small amounts are manufactured by the adrenal glands located on the top of the kidneys.
Women also produce very small amounts of testosterone.
When a man is deficient in the production of endogenous testosterone, his doctor may recommend he undergo testosterone replacement therapy.
Testosterone base will not typically be the drug of choice for this due to the short half-life.
In such cases, synthetic anabolic androgenic steroids, which are simply variations of the male hormone testosterone, are manufactured in a laboratory to replace testosterone that is not manufactured by the body.
Synthetic testosterone is only recommended for men whose bodies don’t produce adequate amounts of testosterone.
Endogenous testosterone is manufactured and supplied in the Leydig cells of the testicles. Its manufacture and secretions are controlled by the pituitary gland, located in the brain.
Testosterone has a positive influence on a number of behaviors and interactions in the male body:
Hormones must be carefully balanced. Hormones of any kind influence other hormones in the body. Upsetting the balance of one can cause detrimental influences on another.
A person lacking in endogenous testosterone who then turns to testosterone replacement therapy with use of injectable synthetic testosterone must be carefully monitored by a physician to ensure that testosterone levels don’t climb too high.
Putting hormones like testosterone into the body when it is not needed can trigger high testosterone levels. This increases the risk of adverse reactions.
If the body manufactures too much testosterone or a person injects higher than recommended levels of testosterone base, unpleasant side effects may occur.
Testosterone aromatizes to form Estrogen and carries the risk of other side effects that are not present with some other anabolic steroids.
Yet it is widely regarded to be the safest amongst all anabolic steroids.
Physique builders deem Testosterone to be safer than others because it is naturally produced in the body by humans and almost all animals.
The same is not true for other anabolic steroids, which are significantly modified derivatives of natural hormones like nandrolone and testosterone.
Testosterone is generally believed to be the best choice for people who want to use anabolic steroids, and is often recommended for the first cycle of use.
As a naturally existing steroid, Testosterone has been studied for years. Lots of robust information exists about every possible effects testosterone can have in the body, both good and bad.
Surprises with this anabolic steroid are rare. Being a naturally occurring steroid, it is not a strange foreign chemical to the body.
There is more relevant knowledge and medically researched data about testosterone than any other kind of anabolic steroid in the market.
Some of these studies have pointed to the side effects of Testosterone Suspension.
Using anabolic steroids is risky, but it is even riskier to use powerful steroids like testosterone without adequate knowledge of potential adverse health outcomes.
Testosterone is the chief naturally-occurring androgenic steroid in males. Exogenous testosterone is just as androgenic, and comes with some androgenic side effects which are also held to depend on dosage.
Therefore excessive use can lead to androgenic effects.
Dihydrotestosterone (DHT), a metabolite that results when testosterone is metabolized by the 5-alpha-reductase enzyme, is the primary carrier of androgenic effects associated with the intake of testosterone.
5-alpha-reductase (5AR) is an enzyme found in significant quantities in the scalp, prostate, skin and other parts of the body.
As it reacts with the increased androgens introduced to the body with doses of Testosterone Suspension, it can produce DHT in excess amounts.
The DHT produced from this reduction is five times more androgenic than Testosterone, and it is the leading cause of androgenic effects like acne, baldness, benign prostatic hypertrophy, increased growth of facial hair and oily skin amongst others.
Bodybuilders attempt to address the androgenic effects caused by the reaction of testosterone by 5AR reaction with the use of 5AR inhibitors like Propecia, Finasteride, and Proscar.
These inhibitors are reported to efficiently foreclose the androgenic effects of Testosterone Suspension by reducing the level of circulating DHT.
Though these drugs are believed to reduce androgenic effects caused by DHT, they are not held to eliminate androgenic side effects entirely.
This is because Testosterone, on its own also possess some androgenic effects independent of DHT.
When bodybuilders experience androgenic side effects like acne or the beginning signs of male pattern baldness, DHT blocker ointments like Nizoral are also frequently administered on the affected areas of the skin.
An often recommended product in this category is Nizoral, which has Ketoconazole as its main active ingredient.
When Testosterone and other anabolic steroids are taken at performance-level doses, they can reduce or stop completely the natural process of producing Testosterone in the body.
This is known as Hypothalamic Pituitary Testicular Axis (HPTA) shutdown.
The HPTA uses a negative feedback loop to moderate levels of testosterone in the body. When supraphysiological amounts of androgens are introduced to the body, the HPTA determines that the body has sufficient levels of testosterone and decreases or halts its production.
After undergoing a anabolic steroidcycle, bodybuilders usually engage in Post Cycle Therapy (PCT) to help stimulate the production of endogenous Testosterone by activating the physiological function of the HPTA.
Even with a PCT program, the performance user stands the risk of developing permanent hypogonadism.
This Testosterone insufficiency can only be treated with Testosterone Replacement Therapy (TRT).
For most anabolic hormones to be orally active, they need to have an alkyl group on their C-17-alpha carbon.
This is not the case in the structure of Testosterone, which is virtually always administered through injection for bodybuilding purposes.
Testosterone is not held to have any hepatotoxic effects.
A 1976 study used oral doses of testosterone as high as 400mg every day, for 20 days, which added up to be 2,800mg per week.
After the study, it was established that the interaction of Testosterone with hepatocytes during the first-pass metabolism did not cause the liver cells any toxicity.
Also, the study did not observe any negative change in the concentration of liver enzymes.
Following the result of these studies, researchers are confident that ingestion of Testosterone, or even its intravenous administration, do not have hepatotoxic effects.
Before taking any kind of synthetic testosterone, do your homework about testosterone-base and the types of esters attached to it. Benefits don’t always outweigh risks of use.TestosteroneTestosterone 400Testosterone AcetateTestosterone AnabolicTestosterone BaseTestosterone BlendTestosterone CycleTestosterone CypionateTestosterone DecanoateTestosterone EnanthateTestosterone Enanthate 250Testosterone Enanthate CycleTestosterone Enanthate DosageTestosterone EstersTestosterone IsocaproateTestosterone Kick In TimeTestosterone Muscle BuildingTestosterone PCTTestosterone Only CycleTestosterone PhenylpropionateTestosterone PropionateTestosterone Propionate CycleTestosterone Propionate DosageTestosterone ResultsTestosterone Steroid Cycle BeginnersTestosterone Steroid for SaleTestosterone Steroid InjectionsTestosterone SteroidsTestosterone Steroid Side EffectsTestosterone SuspensionTestosterone UndecanoateTest Sustanon CycleHow to Take TestosteroneMale Testosterone Cycle